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While most patients tolerate it well, common side effects can include nausea, diarrhea, and fatigue, which are generally mild and improve over time

Using smaller dose adjustments could reduce nausea, vomiting, and diarrhoea, which may be beneficial for people who experience severe gastrointestinal symptoms

In CKD, uremic dysbiosis causes a decrease in microbial diversity, favoring the growth of pathogenic microbes that raise levels of compounds such as TMAO

There is early research on experimental GLP-1 patches for various conditionsusing advanced microneedle delivery systems, but these remain in preclinical stages